Work

FIGURE 3 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry

Year: 2023

Type: other

Abstract: Differential ATAC signal analysis of human TNBC cell lines identified ancestry-associated genes within differentially accessible chromatin regions across all genomic elements. Genes are displayed on a volcano plot, where the y-axis shows statistical significance (plotted as −log10 FDR) and the x-axis shows the differences between each ancestry group (plotted as log2 fold change). The horizontal dashed lines depict our specified significance cut-off points, with genes that showed an FDR < 0.05 and a |log2FC| > 1 shown in red. Negative log2 fold change values show genes differentially open or up in AA donor cell lines, while positive log2 fold change values show genes differentially open or up in EA donor cell lines.

DOI: 10.1158/2767-9764.24250528.v1

Authors: Alexandra R. Harris, Gatikrushna Panigrahi, Huaitian Liu, Vishal N. Koparde, Maeve Bailey-Whyte, Tiffany H. Dorsey, Clayton C. Yates, Stefan Ambs

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4387364781

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