Supplementary Figure 1 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure 1. Quantified genetic ancestry in TCGA participants by self-reported race. Using published ancestry annotations from Carrot-Zhang et al1, quantified genetic ancestry was compared to self-reported race (SRR). For 111/112 TCGA samples used in our study, genetic ancestry consensus was concordant with SRR. Genetic ancestry consensus classification of African or admixed African ancestry captured 100% of TCGA participants who self-identified as “Black or African American”. Genetic ancestry consensus classification of EUR ancestry captured 98.7% of TCGA participants who self-identified as “White”; in one case, a participant that self-identified as White demonstrated a higher proportion of admixed American genetic ancestry. Among TCGA participants who self-identified as Black or African American, the average percentage of African ancestry was 83.2%, which is comparable to the quantified genetic ancestry estimates for the human cell lines used in this study that were classified as African American-derived (average African ancestry of 79.5%). Among TCGA participants who self-identified as White, the average percentage of European ancestry was 96.7%, which is comparable to the quantified genetic ancestry estimates for the human cell lines used in this study that were classified as European American-derived (average European ancestry of 93.0%).
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4387364787