Characteristics and Outcomes Among Adults Aged ≥60 Years Hospitalized with Laboratory-Confirmed Respiratory Syncytial Virus — RSV-NET, 12 States, July 2022–June 2023
Year: 2023
Type: article
Study design: Observational Study
Abstract: Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in older adults. In May 2023, two RSV vaccines were approved for prevention of RSV lower respiratory tract disease in adults aged ≥60 years. In June 2023, CDC recommended RSV vaccination for adults aged ≥60 years, using shared clinical decision-making. Using data from the Respiratory Syncytial Virus-Associated Hospitalization Surveillance Network, a population-based hospitalization surveillance system operating in 12 states, this analysis examined characteristics (including age, underlying medical conditions, and clinical outcomes) of 3,218 adults aged ≥60 years who were hospitalized with laboratory-confirmed RSV infection during July 2022-June 2023. Among a random sample of 1,634 older adult patients with RSV-associated hospitalization, 54.1% were aged ≥75 years, and the most common underlying medical conditions were obesity, chronic obstructive pulmonary disease, congestive heart failure, and diabetes. Severe outcomes occurred in 18.5% (95% CI = 15.9%-21.2%) of hospitalized patients aged ≥60 years. Overall, 17.0% (95% CI = 14.5%-19.7%) of patients with RSV infection were admitted to an intensive care unit, 4.8% (95% CI = 3.5%-6.3%) required mechanical ventilation, and 4.7% (95% CI = 3.6%-6.1%) died; 17.2% (95% CI = 14.9%-19.8%) of all cases occurred in long-term care facility residents. These data highlight the importance of prioritizing those at highest risk for severe RSV disease and suggest that clinicians and patients consider age (particularly age ≥75 years), long-term care facility residence, and underlying medical conditions, including chronic obstructive pulmonary disease and congestive heart failure, in shared clinical decision-making when offering RSV vaccine to adults aged ≥60 years.
Authors: Fiona P. Havers, Michael Whitaker, Michael Melgar, Bhoomija Chatwani, Shua J. Chai, Nisha B. Alden, James Meek, Kyle P. Openo, Patricia A. Ryan, Sue Kim, Ruth Lynfield, Yomei P. Shaw, Grant Barney, Brenda L. Tesini, Melissa Sutton, H. Keipp Talbot, Kristen P. Olsen, Monica E. Patton, RSV-NET Surveillance Team, RSV-NET Surveillance Team, Pam Daily Kirley, Elizabeth Austin, Daewi Kim, Chandler Surell, Maya Monroe, Lauren Leegwater, Erica Mumm, Molly Bleecker, Adam Rowe, Kevin Popham, Arilene Novak, William Schaffner, Holly Staten
Institutions: Emory University, Veterans Health Administration, Georgia Department of Public Health, Minnesota Department of Health, Colorado Department of Public Health and Environment, Yale University, Maryland Department of Health, Michigan Department of Health and Human Services, University of New Mexico, New York State Department of Health, University of Rochester Medicine, University of Rochester, Oregon Health Authority
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Yale University
OpenAlex ID: W4387378347