Work

Augmentation of Omicron pathogenicity in hamsters using intratracheal inoculation

Year: 2023

Type: preprint

Abstract: The Omicron variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with BA.1 Omicron recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.

Source: Research Square

DOI: 10.21203/rs.3.rs-3398781/v1

Authors: Julia R. Port#, Claude Kwe Yinda, Jonathan E. Schulz, Carl. I. Shaia, Vincent J. Munster

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Emory University, National Institutes of Health, National Institute of Allergy and Infectious Diseases