Work

Author Response: RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

Year: 2023

Type: peer-review

Abstract: Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.

Source: eLife

DOI: 10.7554/elife.85921.3.sa4

Authors: Julie C Necarsulmer, Jeremy M Simon, Baggio Evangelista, Youjun C Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl Moy, Todd Cohen

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4387539738

Cites:

Cited by:

Related to: 10