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Adaptability to eccentric exercise training is diminished with age in female mice

Year: 2023
Type: article
Abstract: The ability to adapt to exercise training may help prevent and combat sarcopenia. Here, we demonstrate young mouse muscles get stronger whereas older mouse muscles become weaker after repeated bouts of eccentric contractions, and that numerous genes were differentially expressed between age groups following training. These results highlight that molecular and functional plasticity is not fixed in skeletal muscle with advancing age, and the ability to handle or cope with physical stress may be impaired.
DOI: 10.1152/japplphysiol.00428.2023
Authors: Cory W. Baumann, Colleen S. Deane, Timothy Etheridge, Nathaniel J. Szewczyk, Craig R. G. Willis, Dawn A. Lowe
Institutions: Ohio University, University of Exeter, Southampton General Hospital, University of Southampton, University of Bradford, University of Minnesota
Language: English
Open Access status: green
Funders: American Federation for Aging Research, Glenn Foundation for Medical Research, UK Research and Innovation, Fondation pour la Recherche Médicale, National Institutes of Health, Medical Research Council, National Institute on Aging
Awards: G1844919077, G2055433861, Are mechanisms of skeletal muscle atrophy simply the reverse of muscle hypertrophy across age? A multi-omics approach, G6837530016, G728849396, Interaction of estrogen, age, and activity on musculoskeletal strength in females, G903003795
OpenAlex ID: W4387563583
FWCI: 0.522
Cites: 92
Cited by: 7
Related to: 10