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Antinociceptive effect of the calcitonin gene-related peptide receptor antagonist BIBN4096BS in mice with bacterial cystitis

Year: 2023
Type: article
Abstract: Afferent C fibers release neuropeptides including calcitonin gene-related peptide (CGRP). Here, we show that the specific CGRP receptor antagonist, BIBN409BS, ameliorates lower urinary tract symptoms and pelvic allodynia in mice inoculated with uropathogenic E. coli. Using fluorescent in situ hybridization, we identified a population of suburothelial fibroblasts in the lamina propria that expresses the canonical CGRP receptor. Our findings indicate that CGRP contributes to the transmission of nociceptive information arising from the bladder.
DOI: 10.1152/ajprenal.00217.2023
Authors: Nicolas Montalbetti, Marianela G. Dalghi, Tanmay Parakala-Jain, Dennis Clayton, Gerard Apodaca, Marcelo D. Carattino
Language: English
Subfield: Urology
Field: Medicine
Open Access status: green
Funders: University of Pittsburgh, National Institutes of Health, NIH Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases, American Urological Association
Awards: G1538230363, G32911834, G354102407, G6723085489, Pittsburgh Center for Kidney Research, Role of PIEZO Channels in Bladder Function and Dysfunction, Leica Stellaris Confocal for Kidney Imaging Core, Pittsburgh Center for Kidney Research, Role of acid-sensing ion channels in bladder sensory signaling, Role of AJC in umbrella cell function and dysfunction
OpenAlex ID: W4387563680
FWCI: 2.343
Cites: 50
Cited by: 8
Related to: 10