Year: 2023
Type: article
Abstract: CPDA.All those units were less than 7 days old.One aliquot from each unit was irradiated, while the other was left unaltered.Samples were collected from the aliquot bags every four hours from 0-28 h.Samples were analyzed on a Radiometer ABL 835 Blood Gas Analyzer for whole blood K+ levels.Results/Findings: Prior to the irradiation, at 0 h, mean K+ level was 13.4 mmol/L (9.9 to 19.8 mmol/L) for AS1, 12.4 mmol/L (8.3 to 17.0 mmol/L) for AS3 and 19.7 mmol/L (17.6 to 22.9 mmol/L) for CPDA.Lowest level of K+ among non-irradiated fresh red cells was 8.0 mmol/L (AS3) at 4 h and the highest level was 24.1 mmol/L (CPDA) at 28 h.Lowest level of K+ among irradiated fresh red cells was 8.4 mmol/L (AS3) at 0 h and the highest K+ level was >25 mmol/L (exceeding the maximum level of instrument detection) reached at 8 h in the CPDA unit.Conclusions: There is a significant variability in K+ levels between non-irradiated fresh red cells with the lowest K+ levels noted in AS3 and the highest in CPDA fresh red cell units.Irradiated CPDA red cells quickly reached high K+ level.This experiment confirmed what has been known that levels of K+ are higher in irradiated compared to non-irradiated red cell units.Additional studies are needed to determine acceptable levels of K+ in irradiated red cell units to protect against hyperkalemia.
Source: Transfusion
Authors: M. Correa Medina, M. Maldonado, C. Villamin, R. Bassett, F. Martinez, K. Klein, A. Knopfelmacher Couchonal, B. Engel, R. Gonta, J. Kelley
Institution: The University of Texas MD Anderson Cancer Center
Language: Spanish
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4387571887