Year: 2023
Type: article
Abstract: Compromised structure and function of the blood-brain barrier (BBB) is one of the pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has been associated with modified expression of tight junction (TJ) proteins, including occludin. Recent evidence indicated occludin as a redox-sensitive, multifunctional protein that can act as both an NADH oxidase and influence cellular metabolism through AMPK kinase. One of the newly identified functions of occludin is its involvement in regulating HIV-1 infection. Studies suggest that occludin expression levels and the rate of HIV-1 infection share a reverse, bidirectional relationship; however, the mechanisms of this relationship are unclear. In this review, we describe the pathways involved in the regulation of HIV-1 infection by occludin. We propose that occludin may serve as a potential therapeutic target to control HIV-1 infection and to improve the lives of people living with HIV-1.
Source: Fluids and Barriers of the CNS
Institutions: University of Miami, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,190
Funders: American Heart Association, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Fundação Oswaldo Cruz, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases
Awards: G1056143923, G1309373569, G245899495, G4561902341, G4884849085, G5109670522, G5158437988, G5775888695, G5782999685, G5943719250, G628684116, G6492298721, G7023517751, G7068466250, G7224178199, Targeting Inflammasomes in Substance Abuse and HIV, G7822443850, G897712522, HIV-1 and amyloid beta interactions at the blood-brain barrier, Defining brain pericytes as a novel and myeloid-derived HIV reservoir
OpenAlex ID: W4387652091