Work

A mitochondrial checkpoint to adaptive anticancer immunity

Year: 2023

Type: article

Abstract: BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.

Source: OncoImmunology

DOI: 10.1080/2162402x.2023.2271693

Authors: Oliver Kepp, Peng Liu, Guido Kroemer, Lorenzo Galluzzi

Institutions: Inserm, Institut Universitaire de France, Université Paris Cité, Université Paris-Saclay, Institut Gustave Roussy, Sorbonne Université, Centre de Recherche des Cordeliers, Hôpital Européen Georges-Pompidou, Weill Cornell Medicine

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913

Funders: Leukemia and Lymphoma Society, Association pour la Recherche sur le Cancer, Equipex, European Commission, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Ligue Contre le Cancer, Centre National de la Recherche Scientifique, Institut Universitaire de France, Institut National Du Cancer, European Research Council, Horizon 2020, National Cancer Institute

Awards: Next-generation phenotypic screening for oncological applications, G2786066923, G434337789, Université de Paris, Dynamics of Immune Response in Irradiated Rectal Cancer, Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer

OpenAlex ID: W4387694795

FWCI: 0.318

Cites: 12

Cited by: 3

Related to: 10