Year: 2023
Type: article
Abstract: Background During exercise, a healthy arterial system facilitates increased blood flow and distributes it effectively to essential organs. Accordingly, we sought to understand how arterial stiffening might impair cardiorespiratory fitness in community‐dwelling individuals. Methods and Results Arterial tonometry and maximum effort cardiopulmonary exercise testing were performed on Framingham Heart Study participants (N=2898, age 54±9 years, 53% women, body mass index 28.1±5.3 kg/m 2 ). We related 5 arterial stiffness measures (carotid‐femoral pulse wave velocity [CFPWV]: a measure of aortic wall stiffness; central pulse pressure, forward wave amplitude, characteristic impedance: measures of pressure pulsatility; and augmentation index: a measure of relative wave reflection) to multidimensional exercise responses using linear models adjusted for age, sex, resting heart rate, habitual physical activity, and clinical risk factors. Greater CFPWV, augmentation index, and characteristic impedance were associated with lower peak oxygen uptake (VO 2 ; all P <0.0001). We observed consistency of associations of CFPWV with peak oxygen uptake across age, sex, and cardiovascular risk profile (interaction P >0.05). However, the CFPWV‐peak oxygen uptake relation was attenuated in individuals with obesity ( P =0.002 for obesity*CFPWV interaction). Higher CPFWV, augmentation index, and characteristic impedance were also related to cardiopulmonary exercise testing measures reflecting adverse O 2 kinetics and lower stroke volume and peripheral O 2 extraction but not to ventilatory efficiency, a prognostic measure of right ventricular‐pulmonary vascular performance. Conclusions Our findings delineate relations of arterial stiffness and cardiorespiratory fitness in community‐dwelling individuals. Future studies are warranted to evaluate whether the physiological measures implicated here may represent potential targets for improving cardiorespiratory fitness in the general population.
Institutions: Boston University, Framingham Heart Study, University of Michigan, Michigan Medicine, Vanderbilt University Medical Center, Harvard University, Massachusetts General Hospital, VA Boston Healthcare System, National Heart, Lung, and Blood Institute, The University of Texas at San Antonio Health Science Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,700
Awards: The Role of Histone Deacetylase 9 in Vascular Calcification, Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise Training, G250621538, G278200998, G3405256882, G4976486911, Molecular markers of early cardiometabolic health transitions in the CARDIA study, The Framingham Heart Study, Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance, Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
OpenAlex ID: W4387728469