Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia
Year: 2023
Type: article
Study design: Observational Study
Abstract: We evaluated disparities in disease burden, organ dysfunction, vital signs, and timing of therapy in children newly presenting with acute leukemia. Among 899 patients with acute leukemia diagnosed at two large children's hospitals, a priori lab-based definitions of high disease burden, infection risk, renal dysfunction, and coagulopathy were applied to electronic health record data. Black patients with acute myeloid leukemia had increased prevalence of elevated white blood cell count and uric acid; Black patients with acute lymphoblastic leukemia demonstrated increased prevalence of coagulopathy. Black patients' presentation more frequently included multiple lab abnormalities consistent with advanced physiologic dysfunction. No differences were found in days to therapy initiation.
Source: Pediatric Blood & Cancer
DOI: 10.1002/pbc.30726
Institutions: University of California, San Francisco, UCSF Benioff Children's Hospital, UCSF Helen Diller Family Comprehensive Cancer Center, University of Pennsylvania, Children's Hospital of Philadelphia, Baylor College of Medicine, Texas Children's Hospital, Seattle Children's Hospital, University of Washington, Emory University, Children's Healthcare of Atlanta
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,330
OpenAlex ID: W4387764971