Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study
Year: 2023
Type: article
Study design: Observational Study
Abstract: Primary bone diffuse large B-cell lymphoma is a rare variant of extranodal non-Hodgkin lymphoma historically treated with induction chemotherapy followed by consolidative radiation therapy (RT). It remains unknown whether RT confers additional benefit following rituximab-based chemoimmunotherapy (CIT) induction in patients with limited stage disease. We conducted a multicenter, retrospective analysis of patients treated between 2005 and 2019 using rituximab-based CIT regimens with or without consolidative RT to discern whether consolidative RT adds benefit in patients with stage I-II disease that could be encompassed in one radiation field. A total of 112 patients were included: 78 received CIT and radiation (RT group), and 34 received CIT alone (no RT group). The overall survival at 10 years was 77.9% in the RT group and 89.0% in the no RT group (P=0.42). The relapse-free survival at 10 years was 73.5% in the RT group and 80.3% in the no RT group (P=0.88). Neither improved overall survival nor relapse-free survival was associated with the addition of consolidative RT. Subgroup analysis of patients only achieving a partial response after CIT suggests that these patients may benefit from consolidative RT.
Source: Haematologica
Authors: Alexandra Rezazadeh, Aniko Szabo, Arushi Khurana, David J. Inwards, Matthew A. Lunning, Nancy L. Bartlett, Paolo F. Caimi, Thomas D. Rodgers, Paul M. Barr, Sayan Mullick Chowdhury, Narendranath Epperla, Hiruni Mendries, Brian T. Hill, Timothy S. Oh, Reem Karmali, Julie E. Chang, Gaurav Goyal, Benjamin M. Parsons, Krista M. Isaac, Craig A. Portell, Kathleen Monahan, Malika Siker, David M. King, Timothy S. Fenske
Institutions: Medical College of Wisconsin, Mayo Clinic, Washington University in St. Louis, Case Western Reserve University, University of Rochester, The Ohio State University, Cleveland Clinic, Northwestern University, University of Wisconsin–Madison, University of Alabama at Birmingham, Gundersen Health System, University of Virginia
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,157
OpenAlex ID: W4387765689