Work

The era of the ARG: an empiricist's guide to ancestral recombination graphs

Year: 2023

Type: preprint

Abstract: (ARG). An ARG extensively encodes the ancestry of the genome(s) and thus is replete with valuable information for addressing diverse questions in evolutionary biology. Despite its potential utility, technological and methodological limitations, along with a lack of approachable literature, have severely restricted awareness and application of ARGs in empirical evolution research. Excitingly, recent progress in ARG reconstruction and simulation have made ARG-based approaches feasible for many questions and systems. In this review, we provide an accessible introduction and exploration of ARGs, survey recent methodological breakthroughs, and describe the potential for ARGs to further existing goals and open avenues of inquiry that were previously inaccessible in evolutionary genomics. Through this discussion, we aim to more widely disseminate the promise of ARGs in evolutionary genomics and encourage the broader development and adoption of ARG-based inference.

Source: PubMed

DOI: 10.48550/arxiv.2310.12070

Authors: Lewanski, Alexander L., Grundler, Michael C., Bradburd, Gideon S.

Institutions: University of Michigan, Michigan State University

Language: English

Topic: Genomics and Phylogenetic Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Defense, Michigan State University, National Institutes of Health, College of Engineering, Michigan State University, National Defense Science and Engineering Graduate, National Institute of General Medical Sciences

Awards: G2319531065, G9000129031

OpenAlex ID: W4387801522

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Cited by: 3

Related to: 10