Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer
Year: 2023
Type: article
Abstract: Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus. In this study, we leverage human-derived microphysiological models to reverse-engineer the HIV-immune system interaction and evaluate the potential of memory-like natural killer cells for HIV + head and neck cancer, one of the most common tumors in patients living with human immunodeficiency virus. Here, we evaluate multiple aspects of the memory-like natural killer cell response in human-derived bioengineered environments, including immune cell extravasation, tumor penetration, tumor killing, T cell dependence, virus suppression, and compatibility with retroviral medication. Overall, these results suggest that memory-like natural killer cells are capable of operating without T cell assistance and could simultaneously destroy head and neck cancer cells as well as reduce viral latency.
Source: Nature Communications
Authors: Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,290
Funders: National Science Foundation, U.S. Department of Health and Human Services, University of Wisconsin Carbone Cancer Center, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Division of Chemical, Bioengineering, Environmental, and Transport Systems
Awards: G1277949577, Stress keratin 17 and CD4/8 ratio as prognostic markers in HIV-related anogenital squamous cell precancers and cancers (Biospecimens/Biocohort), G245506646, CAREER: High-throughput Imaging of Drug Response in Tumor Organoids, G3115918347, Cellular level optical metabolic imaging to predict drug response in cancer, (PQ7) Quantitative in vivo optical imaging of tumor heterogeneity, G4004214011, G4266173978, G42679306, G4305155978, G4660062756, G5112762073, G563639681, G6768193147, G6821238466, G6954746270, G7279594894, G745260057, G7505140584, The Cell Biology of HIV-1 Genome Trafficking, G9000011210, G9000012471, G9000058198, G9000090838, G9000265189, Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoids
OpenAlex ID: W4387844683