How do gravity alterations affect animal and human systems at a cellular/tissue level?
Year: 2023
Type: article
Abstract: The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: "How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?" This is one of the five major scientific issues of the ESA roadmap "Biology in Space and Analogue Environments". Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.
Source: npj Microgravity
Authors: Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Choukér, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raúl Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Institutions: University of Florence, Ohio University, Scuola Superiore Sant'Anna, Belgian Nuclear Research Centre, Association Francaise contre les Myopathies, Goethe University Frankfurt, University of Milan, LMU Klinikum, Ludwig-Maximilians-Universität München, Institute of Molecular Bioimaging and Physiology, National Research Council, Centre National de la Recherche Scientifique, École Pratique des Hautes Études, Sorbonne Université, Institut de Systématique, Évolution, Biodiversité, University of Pavia, Italian Institute of Technology, Institute of Applied Science and Intelligent Systems, University of Siena, University of Bari Aldo Moro, Stress, IMmunité, PAthogènes, Université de Lorraine, Technische Universität Dresden, Aarhus University, Otto-von-Guericke-Universität Magdeburg, Inserm, SAnté INgenierie BIOlogie Saint-Etienne, Université Jean Monnet, Université Jean Monnet, European Space Agency, Consejo Superior de Investigaciones Científicas, Centro de Investigaciones Biológicas Margarita Salas, Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR), Université Libre de Bruxelles, Aristotle University of Thessaloniki, Academic Center for Dentistry Amsterdam, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Utrecht University, University Medical Center Utrecht, Ifremer, Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, TU Wien, Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Université Toulouse III - Paul Sabatier, Évolution et Santé Orale, Université de Montpellier, Marine Biodiversity Exploitation and Conservation, Institut de Recherche pour le Développement, University of Bristol, University of Pisa, Istituto Superiore di Sanità, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Ospedale Policlinico San Martino, University of Genoa, Aschaffenburg University of Applied Sciences, Vrije Universiteit Brussel
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,290
OpenAlex ID: W4387844698