Work

Intestinal metabolomics in premature infants with late-onset sepsis

Year: 2024

Type: article

Abstract: We aimed to investigate the characteristics of intestinal metabolomics and non-invasive biomarkers for early diagnosis of late-onset sepsis (LOS) by analyzing gut metabolites in preterm infants with LOS. We collected stool samples from septic and healthy preterm infants for analysis by liquid chromatography-mass spectrometry. 123 different metabolites were identified and 13 pathways were mainly involved. Glycine, serine, and threonine metabolism; glyoxylate and dicarboxylic acid metabolism; glutathione metabolism; primary bile acid biosynthesis; steroid synthesis; pentose and glucuronic acid interconversion may be involved in the pathogenesis of LOS in preterm infants. The significant changes of N-Methyldopamine, cellulose, glycine, gamma-Glutamyltryptophan, N-Ribosylnicotinamide and 1alpha, 25-dihydroxycholecalciferol showed specific diagnostic values and as non-invasive biomarkers for LOS.

Source: Scientific Reports

DOI: 10.1038/s41598-024-55398-7

Authors: Jingfei Liu, Li Zhang, Dong Li, Xiaotong Yu, Ying Gao, Ying Zhou

Institutions: Dalian Maternal and Child Health Hospital, Dalian Medical University, Second Affiliated Hospital of Dalian Medical University, First Affiliated Hospital of Dalian Medical University

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590