Work

Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia

Year: 2023

Type: article

Abstract: The role of astrocytes in H-reflex hyperexcitability following SCI remains understudied. Our findings establish a relationship between GLT-1 expression, its proximity to neuronal PSD-95 in the spinal cord ventral horn, and the loss of H-reflex RDD, i.e., hyperreflexia. Our findings provide a new perspective on synaptic alterations and the development of SCI-related spasticity.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00234.2023

Authors: Curtis A. Benson, Jared F. King, Sierra D. Kauer, Stephen G. Waxman, Andrew M. Tan

Institutions: Yale University, VA Connecticut Healthcare System

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Paralyzed Veterans of America Research Foundation