Year: 2023
Type: preprint
Study design: Observational Study
Abstract: BACKGROUND: Persistent symptoms among some persons who develop COVID-19 has led to the hypothesis that SARS-CoV-2 may, in some form or location, persist for long periods following acute infection. Several studies have shown data in this regard but are limited by non-representative and small study populations, short duration since acute infection, and lack of a true-negative comparator group to assess assay specificity. METHODS: (Quanterix) single molecule array detection platform to measure SARS-CoV-2 spike, S1, and nucleocapsid antigens. RESULTS: Compared to 250 pre-pandemic participants who had 2% assay positivity, detection of any SARS-CoV-2 antigen was significantly more frequent among 171 pandemic-era participants at three different time periods in the post-acute phase of infection. The absolute difference in SARS-CoV-2 plasma antigen prevalence was +11% (95% CI: +5.0% to +16%) at 3.0-6.0 months post-onset of COVID-19; +8.7% (95% CI: +3.1% to +14%) at 6.1 to 10.0 months; and +5.4% (95% CI: +0.42% to +10%) at 10.1-14.1 months. Hospitalization for acute COVID-19 and, among the non-hospitalized, worse self-reported health during acute COVID-19 were associated with greater post-acute phase antigen detection. CONCLUSIONS: Compared to uninfected persons, there is an excess prevalence of SARS-CoV-2 antigenemia in SARS-CoV-2-infected individuals up to 14 months after acute COVID-19. These findings motivate an urgent research agenda regarding the short-term and long-term clinical manifestations of this viral persistence.
Source: medRxiv
Authors: Michael J. Peluso, Zoe N. Swank, Sarah A. Goldberg, Scott Lu, Thomas Dalhuisen, Ella Borberg, Yasmeen Senussi, Michael A. Luna, Celina Chang Song, Alexus Clark, Andhy Zamora, Megan Lew, Badri Viswanathan, Beatrice Huang, Khamal Anglin, Rebecca Hoh, Priscila Y. Hsue, Matthew S. Durstenfeld, Matthew A. Spinelli, David V. Glidden, Timothy J. Henrich, J. Daniel Kelly, Steven G. Deeks, David R. Walt, Jeffrey N. Martin
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Evaluation of the Impact of HIV Status on the Immune Response to mRNA COVID-19 Vaccines, Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic, UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC), Targeting Non Viral Markers of HIV Persistence, Dissecting the signals that maintain HIV-specific CD8+ T cell exhaustion, Characterizing the virologic and immunologic signatures of HIV exceptional control
OpenAlex ID: W4387933449