Work

Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?

Year: 2023

Type: article

Abstract: Objective: To examine the relationship between weight trajectory and 2-year neurodevelopmental outcomes for extremely low birthweight (ELBW) infants with BPD. Study Design:Secondary analysis of infants born from 2010 to 2019. The predictor was BPD severity and the outcome was neurodevelopmental impairment, defined as any Bayley Scales of Infant Development (BSID) III score <70 at 24 months’ corrected age. Repeated measures logistic regression was performed. Results: There were 5,042 infants included. Faster weight trajectory was significantly associated with a decreased probability of having at least one BSID III score <70 for infants with grade 1-2 BPD (p<0.0001) and an increased probability of having at least one BSID III score <70 for infants with grade 3 BPD (p<0.009). There was no significant association between weight trajectory and BSID III score <70 for infants with grade 0 BPD. Conclusion: The association between postnatal weight trajectory and neurodevelopmental outcome differs by BPD severity.

Source: Journal of Perinatology

DOI: 10.1038/s41372-023-01808-z

Authors: Fernando A. Munoz, Emily Hawkins Carter, Erika M. Edwards, Maggie Jerome, Jonathan S. Litt

Institutions: Oregon Health & Science University, University of Vermont, Vermont Oxford Network, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Infant Development and Preterm Care

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development