Year: 2023
Type: article
Abstract: experiments with Nile red encapsulation showed cytocompatibility and CNS infiltration of nanocarriers. Administered 4 or 28 hours after stroke onset, the nanoformulation provided significant neuroprotection, reducing infarct volume by ∼50% compared to controls. It outperformed orally-administered 5BDBD with a lower dose and shorter treatment duration, suggesting precise delivery by nanoformulation improves outcomes. The fluorescent nanoformulations may serve as a platform for delivering and tracking therapeutic agents for stroke treatment.
Source: Biomaterials Science
DOI: 10.1039/d3bm00951c
Institutions: UConn Health, University of Connecticut, Yale University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Funders: American Heart Association, National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences, Congressionally Directed Medical Research Programs, U.S. Army Medical Research Acquisition Activity
Awards: G1044130170, Biodegradable Matrices with Structural and Physical Cues for Interface Engineering, G2609835305, Biodegradable Matrices for Bone Healing, G3458581170, G405246344, G481858457, Engineering Composite Nanofibrous Scaffolds for Repairing Segmental Bone Defect, Therapeutic implications of purinergic receptor P2X4 in ischemic stroke, Engineered Matrices with Electrical and Chemical Stimulation for Peripheral Nerve Repair, G8316532672, G9000219556, Polysaccharide putty formulations for tissue regeneration, Yale Clinical and Translational Science Award
OpenAlex ID: W4388014272