Latent Childhood Exposure to Mixtures of Metals and Neurodevelopmental Outcomes in 4–5-Year-Old Children Living in Spain
Year: 2023
Type: article
Abstract: Neurodevelopmental disorders are increasing globally, and metal exposure may play a significant role as an environmental factor. This cross-sectional study aimed to identify metal mixture patterns and assess their impact on children’s neurodevelopment. Data from 962 children (aged 4–5 years) participating in the Spanish INMA cohort study were analysed. Urinary metal concentrations (cobalt (Co), copper (Cu), molybdenum (Mo), selenium (Se), lead (Pb), zinc (Zn), and arsenic speciation) were used as exposure biomarkers. Principal component analysis (PCA) revealed four latent exposure variables representing uncorrelated metal mixture patterns. Linear regression analyses examined the associations between these variables and children’s neuropsychological functions assessed through the McCarthy Scales of Children’s Abilities. The first latent exposure variable (Cu, Se, Pb, Zn) and the second (inorganic arsenic, monomethylarsonic acid) showed negative associations with verbal executive function (ß = − 1.88, 95% confidence interval (CI) = − 3.17 to − 0.59) and gross motor function (ß = − 1.41, 95% CI = − 2.36 to − 0.46), respectively. Conversely, the third variable (Mo, Co) and the fourth (arsenobetaine) exhibited positive associations with visual and verbal span functions (ß = 1.14, 95% CI = 0.16 to 2.12) and fine motor function (ß = 1.01, 95% CI = 0.11 to 1.92), respectively. This study suggests that even relatively low levels of metal latent exposures, notably inorganic arsenic and a mixture of metals including Pb, adversely affect children’s neuropsychological development function scores, while exposure to arsenobetaine and a mixture of Co and Mo has a positive impact.
Source: Exposure and Health
Institutions: Dartmouth College, Universitat de Miguel Hernández d'Elx, Universitat Pompeu Fabra, Instituto de Salud Carlos III, Erasmus MC, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of the Basque Country, Biogipuzkoa Health Research Institute, Universidad de Oviedo, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Universitat Jaume I, Universitat de València, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Queen's University Belfast, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Universidad Autónoma de Chile
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,390
Funders: Universidad Miguel Hernández, Fundació la Marató de TV3, Fundación Bancaria Caja de Ahorros de Asturias, Centres de Recerca de Catalunya, Generalitat de Catalunya, Generalitat Valenciana, Universidad de Oviedo, Horizon 2020 Framework Programme, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación, Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana, Ministerio de Universidades, NextGenerationEU
Awards: G1127613529, G1128112482, G115623121, G1251492779, G1263697128, G1288326559, G1298559095, G1382859773, G1422035950, G151081618, G1585958176, G1632783612, G1742557123, G1749994109, G1844925781, G1847050635, G1877160490, G1916465975, G199012823, G1990797403, G200414403, G2030817791, G2064873908, G2163430697, G2206155153, G2262748287, G2337515174, G2347312180, G2382355258, G2387096677, G2412846689, G2462415295, G2605948900, G2620658983, G2625532533, G2628364946, G2672435700, G2814428116, G2843509804, G2867885658, G2986769956, G2992296460, G3005324705, G300979063, G3057128404, G3158803353, G318412399, G3220251042, G3233413551, G3285691745, G3405515844, G3423777635, G3480869486, G3620215414, G3624472861, G3630106664, G3662005835, G3791092396, G3857581125, G3942428422, G4045293325, G410571670, G4123509308, G4141329914, G4145846527, G4151357287, G4194809477, G4242524022, G425668148, G4281347028, G4332878075, G4442566642, G451917667, G4558884256, G4749042089, G4909233925, G5000828053, G5080475149, G5126129994, G5185833053, G520164222, G5222799811, G5306723254, G5372946707, G5628238840, G5759080471, G582682078, G5844070635, G586812122, G5967599077, G6033091583, G6177300850, G621070573, G630914071, G6328075693, G6374753769, G6384254145, G6412857311, G6459147697, G6485243957, G648621315, G6520718613, G6545694585, G6656126374, G6688676418, G6807032611, G683931746, G6840786362, Exposición prenatal a compuestos orgánicos persistentes y obesidad y síndrome metabólico a los 11 años de edad: Un estudio prospectivo de COHORTE, G6999846316, G7053678703, G7169023097, G7208110030, G7232897811, G7255110458, G7296152096, G7426531139, G7507141173, G7509958124, G760317559, G7686082776, G7812052072, G8012477847, G8028653635, G8134712719, G8331390064, G8345267270, G8450998669, G8563013907, G8721596293, G8791571605, Contaminación ambiental por exposición a compuestos tóxicos persistentes y efectos en el desarrollo físico, visual y cognitivo infantil, G8804906264, G8824911526, G929055435, G956958452
OpenAlex ID: W4388041925