Work

Acral melanoma: new insights into the immune and genomic landscape

Year: 2023

Type: article

Abstract: Acral melanoma is a rare subtype of melanoma that arises on the non-hair bearing skin of the nail bed, palms of the hand and soles of the feet. It is unique among melanomas in not being linked to ultraviolet radiation (UVR) exposure from the sun, and, as such, its incidence is similar across populations who are of Asian, Hispanic, African and European origin. Although research into acral melanoma has lagged behind that of sun-exposed cutaneous melanoma, recent studies have begun to address the unique genetics and immune features of acral melanoma. In this review we will discuss the latest progress in understanding the biology of acral melanoma across different ethnic populations and will outline how these new discoveries can help to guide the therapeutic management of this rare tumor.

Source: Neoplasia

DOI: 10.1016/j.neo.2023.100947

Authors: Larissa Anastacio DaCosta Carvalho, Flavia C. Aguiar, Keiran S.M. Smalley, Patricia A. Possik

Institutions: Moffitt Cancer Center, Instituto Nacional de Câncer - INCA

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,170