Gut Microbiota to Microglia: Microbiome Influences Neurodevelopment in the CNS
Year: 2023
Type: review
Abstract: The brain is traditionally viewed as an immunologically privileged site; however, there are known to be multiple resident immune cells that influence the CNS environment and are reactive to extra-CNS signaling. Microglia are an important component of this system, which influences early neurodevelopment in addition to modulating inflammation and regenerative responses to injury and infection. Microglia are influenced by gut microbiome-derived metabolites, both as part of their normal function and potentially in pathological patterns that may induce neurodevelopmental disabilities or behavioral changes. This review aims to summarize the mounting evidence indicating that, not only is the Gut-Brain axis mediated by metabolites and microglia throughout an organism's lifetime, but it is also influenced prenatally by maternal microbiome and diet, which holds implications for both early neuropathology and neurodevelopment.
Source: Children
Authors: Jeffery Bettag, Daniel Goldenberg, Jasmine Carter, Sylvia Morfin, Alison Borsotti, James Fox, Matthew ReVeal, Dylan Natrop, David Gosser, Sree Kolli, Ajay K. Jain
Institution: Saint Louis University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,224
Awards: Role of gut microbiota in total parenteral nutrition associated injury, Role of intestinal microbiota in driving injury mechanisms in short bowel syndrome, G9000097519, Gut region-specific mechanisms that limit dissemination of microbial signals from the intestine, Neuroimmunology of AD and CAA with focus on innate immunity and lymphatics, Role of bile acid receptors FXR and TGR5 in preventing injury in short bowel syndrome, The Saint Louis University Component of the NASH Clinical Research Network
OpenAlex ID: W4388078044