Work

Granulomatous variant of scleromyxedema successfully treated with topical ruxolitinib, dapsone and intravenous immunoglobulin

Year: 2023

Type: article

Abstract: Scleromyxedema (SM) is a progressive, generalized cutaneous mucinosis of unknown etiology. SM is a rare entity with limited reports describing the spectrum of clinical and histologic findings. Clinically, SM is characterized by a generalized papular and sclerodermoid eruption and is commonly associated with an IgG-λ paraproteinemia.1 Histologic examination classically reveals (1) mucin deposition with in the upper and midreticular dermis, (2) fibroblast proliferation, and (3) fibrosis.2 Other mucinoses such as cutaneous myxedema related to thyroid dysfunction must be excluded.

Source: JAAD Case Reports

DOI: 10.1016/j.jdcr.2023.10.010

Authors: Donglin Zhang, Kimberly Sable, Allison Miller, Molly Hinshaw, Timothy Schmidt, Bridget E. Shields

Institution: University of Wisconsin–Madison

Language: English

Topic: Skin Diseases and Diabetes

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $675