Supplementary Figure S5 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
Year: 2023
Type: supplementary-materials
Abstract: Figure S5. (A) Gene Set Enrichment Analysis (GSEA) of BIOCARTA IL-6 pathway; (B) Gene set of IL-6-stimulated cell cultures; (C) Gene set in IL-6-deprived cell cultures. GSEA was performed by 1000 permutations. The maximum and minimum sizes for gene sets were 500 and 15, respectively. The y-axis represents the enrichment score (ES) and the x-axis lists the ranked genes by fold change. Vertical black lines on the x-axis represent the genes in gene sets. The green line connects points of ES and genes. ES is the maximum deviation from zero as calculated for each gene going down the ranked list and represents the degree of over-representation of a gene set at the top or the bottom of the ranked gene list. The P-value and ES are labeled at the top of the figure. The peak towards to left of the x-axis suggests a positive enrichment of the target gene set and vice versa.
Authors: Nan Deng, Laura Reyes-Uribe, Johannes F. Fahrmann, Whittney S. Thoman, Mark F. Munsell, Jennifer B. Dennison, Eunice Murage, Ranran Wu, Ernest T. Hawk, Selvi Thirumurthi, Patrick M. Lynch, Christina M. Dieli-Conwright, Alexander J. Lazar, Sonali Jindal, Khoi Chu, Manoj Chelvanambi, Karen Basen-Engquist, Yisheng Li, Jennifer A. Wargo, Florencia McAllister, James P. Allison, Padmanee Sharma, Krishna M. Sinha, Samir Hanash, Susan C. Gilchrist, Eduardo Vilar
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4388132948