Supplementary Figure S8 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
Year: 2023
Type: supplementary-materials
Abstract: Figure S8. (A) Volcano plot of statistically significant genes and fold-changes between the usual care and exercise groups in DSP assay. Top significantly differentially expressed genes are labeled; (B) The dot plot presents enriched GSEA HALLMARK pathways. The sizes of the dots represent the count of core enrichment (leading-edge) genes. The colors of the dots represent the BH-adjusted P-values. The order of HALLMARK gene sets is based on the gene ratio (number of significant genes associated with the HALLMARK gene sets / total number of significant genes; (C) Total CD8+ T cell density per mm2 (left) and epithelial (right) in colonic mucosa preand post- intervention from usual care (n=4) and exercise (n=4) participants; (D) Total CD57+ NK cell density per mm2 (left) and epithelial (right) in colonic mucosa pre- and post- intervention from usual care (n=4) and exercise (n=4) participants.
Authors: Nan Deng, Laura Reyes-Uribe, Johannes F. Fahrmann, Whittney S. Thoman, Mark F. Munsell, Jennifer B. Dennison, Eunice Murage, Ranran Wu, Ernest T. Hawk, Selvi Thirumurthi, Patrick M. Lynch, Christina M. Dieli-Conwright, Alexander J. Lazar, Sonali Jindal, Khoi Chu, Manoj Chelvanambi, Karen Basen-Engquist, Yisheng Li, Jennifer A. Wargo, Florencia McAllister, James P. Allison, Padmanee Sharma, Krishna M. Sinha, Samir Hanash, Susan C. Gilchrist, Eduardo Vilar
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4388133028