Work

A Nef Precursor or Benign Counterpart: High Prevalence of Healthy Subjects with Antibody Reactivity to the C3-Convertase

Year: 2023

Type: article

Abstract: Key Points There are two anticonvertase antibody populations—Nephritic Factors which cause complement dysregulation and C3CAbs which do not. C3CAbs are highly prevalent in the healthy adult population (>95% prevalence). C3CAbs suggest a direction of study to determine the origin of Nephritic Factors.

Source: Kidney360

DOI: 10.34067/kid.0000000000000260

Authors: Christopher T. Culek, Carla M. Nester

Institutions: University of Iowa, University of Iowa Stead Family Children’s Hospital

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Institute of Diabetes and Digestive and Kidney Diseases