Work

Cryo-EM structure of the human cardiac myosin filament

Year: 2023

Type: article

Source: Nature

DOI: 10.1038/s41586-023-06691-4

Authors: Debabrata Dutta, Vu Nguyen, Kenneth S. Campbell, Raúl Padrón, Roger Craig

Institutions: University of Massachusetts Chan Medical School, University of Kentucky

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Murine 3D Engineered Tissue Model of Human MYBPC3 Mutations, Structure of The Interacting-Heads Motif in Myosin Filaments and Molecules, Mechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein C, Length-dependent activation in human myocardium, Dissecting the structural origin of relaxation in skeletal muscle, Dual filament control of myocardial power and hemodynamics, Structural basis of the super-relaxed state in human cardiac muscle, ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling

OpenAlex ID: W4388142164

FWCI: 30.67

Cites: 86

Cited by: 161

Related to: 10