Work

Cancer vaccines in the clinic

Year: 2023

Type: review

Abstract: Vaccines are an important tool in the rapidly evolving repertoire of immunotherapies in oncology. Although cancer vaccines have been investigated for over 30 years, very few have achieved meaningful clinical success. However, recent advances in areas such antigen identification, formulation development and manufacturing, combination therapy regimens, and indication and patient selection hold promise to reinvigorate the field. Here, we provide a timely update on the clinical status of cancer vaccines. We identify and critically analyze 360 active trials of cancer vaccines according to delivery vehicle, antigen type, indication, and other metrics, as well as highlight eight globally approved products. Finally, we discuss current limitations and future applications for clinical translation of cancer vaccines.

Source: Bioengineering & Translational Medicine

DOI: 10.1002/btm2.10588

Authors: Morgan E. Janes, Alexander P. Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri

Institutions: Harvard University, Harvard–MIT Division of Health Sciences and Technology, Wyss Institute for Biologically Inspired Engineering, Massachusetts Institute of Technology, University of Illinois Chicago

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,750