Work

In-situ complexation of rice starch and nobiletin by extrusion alleviates ulcerative colitis and modulates dysbiosis of intestinal flora in C57BL/6 mice

Year: 2023

Type: article

Abstract: In this study, a rice starch–nobiletin (NOB) complex with well digestion-resistance by in-situ extrusion was chosen as a supplementary diet to protect against ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice. After oral administration, the complex alleviated colon damage caused by DSS, decreased serum levels of proinflammatory cytokines and colon oxidative stress, and improved the expression of tight junction proteins. Meanwhile, the complex may modify the gut microbiota by increasing its diversity and promoting potentially beneficial bacteria, as well as boosting short-chain fatty acid levels. Correlation analysis further revealed that proinflammatory cytokines and other injury factors were negatively related to Firmicutes and Verrucomicrobiota (phylum level), as well as Lactobacillus and Akkermansia (genus level). Overall, our results show that the rice starch–NOB complex protects intestinal barrier dysfunction in UC and may be a healthy addition to rice starch diets.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2023.105875

Authors: Hai He, Xudong Zhang, Wenzhen Liao, Jie Shen

Institutions: The First People's Hospital of Shunde, Southern Medical University, Hainan Medical University

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $2,160