Work

Variations of the Corpus Callosum in Congenital Adrenal Hyperplasia (cah)

Year: 2023

Type: article

Abstract: Congenital adrenal hyperplasia (CAH) is a genetic variant that causes high levels of androgens during gestation in females, whereas levels in males are largely normal. Only little is known about the brain in CAH, and no study has specifically focused on the corpus callosum. Here we compared callosal area measures between 53 individuals with CAH and 53 control participants, who were pair-wise matched with respect to sex (33 women/20 men) and age (mean±SD: 30.2±7.8 years). The corpus callosum was manually outlined on T1-weighted brain images, obtained on a 3 Tesla scanner, and divided into seven sections according to the Witelson scheme (i.e., rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium).

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.1622

Authors: Eileen Luders, Debra Spencer, Caitlin Dale, Melissa Hines, Florian Kurth

Institutions: University of Auckland, University of Cambridge

Language: English

Topic: Sexual Differentiation and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500