Mesenchymal Stem Cell-derived Secretome: a Novel Biopharmaceutical Approach Prevents the Long-term Metabolic Insult Elicited by Perinatal Asphyxia
Year: 2023
Type: article
Abstract: Perinatal asphyxia (PA) constitutes a leading cause of neonatal death, while the surviving children develop motor and cognitive deficits, for which no preventive treatments are available. A new approach is reported. Mesenchymal stem cells (MSCs) secrete a broad array of proteins, regulatory miRNAs, and bioactive factors, with remarkable antioxidant, anti-inflammatory and repairing features. Pre-incubation of MSCs with pro-inflammatory cytokines (TNF-α+IFN-γ) or deferoxamine (DFX, a hypoxia-mimetic greatly improves the protective effect of the secretome.
Source: IBRO Neuroscience Reports
Authors: Paola Morales, Nancy Farfán-Troncoso, Marta Zamorano-Cataldo, Martina Redel-Villaroel, Ingrid Muñoz, Jaime Carril, Tirso Acuña, Dania Reveco, Eduardo Quiñones, Jazmina Bongain, Rocío Rebolledo, Felix Urra, Yedy Israel, María Elena Quintanilla, José Luis Valdés, Fernando Ezquer, Mario Herrera-Marschitz
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4388364539