Work

Influence of Neural Mitochondrial Transfer on Astrocytic Metabolism

Year: 2023

Type: article

Abstract: The maintenance of a proper mitochondrial function and metabolic balance in neural cells is crucial to define cell viability in the central nervous system (1). Sharing of whole, functional mitochondria among neural cells may therefore represent a novel mechanism of metabolic reconfiguration so far overlooked. Accordingly, the intercellular transfer of organelles has proved to physiologically occur in neural cells to define cell survival (2-3). Being mitochondrial content and function key in metabolic and redox regulation (3-4) that control neural cell fate (3,5), the incorporation of exogenous organelles must be strictly regulated.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.457

Authors: Sara Yunta, Rubén Quintana Cabrera, Juan P. Bolanos

Institutions: Universidad de Salamanca, Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas, Instituto Cajal

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500