Year: 2023
Type: article
Abstract: The metabolic footprint of astrocytes is key in supporting neuronal function and survival. The differential regulation of Pfkfb3 coordinates the glycolytic nature of astrocytes and the oxidative nature of neurons (1). Glycolytic-derived metabolites that are shuttled from astrocytes to neurons sustain this metabolic cooperation to facilitate neuronal neurotransmission. The mitochondrial respiratory chain is highly assembled in neurons to sustain high energy efficiency, whereas it is more disassembled in astrocytes to sustain high mitochondrial reactive oxygen species (mROS) production (2). These naturally highly abundant mROS in astrocytes support a transcriptional signature that contributes to the highly active glucose metabolism in these cells that is necessary to sustain brain metabolism and behavior (3). This presentation will sum up these findings (4) and will show novel observations indicating additional key elements that are supportive of the astrocyte-neuronal metabolic coupling. Acknowledgments We acknowledge the technical assistance of Mónica Resch, Lucía Martín, Estefanía Prieto-Garcia, and Mónica Carabias-Carrasco, from the University of Salamanca. JPB is funded by the NextGenerationEU/PRTR and Agencia Estatal de Investigación (10.13039/501100011033; PID2019-105699RB-I00; PDC2021-121013-I00; RED2018–102576‐T); Instituto de Salud Carlos III (CB16/10/00282) and Junta de Castilla y León (CS/151P20 and Escalera de Excelencia CLU-2017-03). References 1. Herrero-Mendez A et al. & Bolaños JP. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol. 11:747-752 (2009) 2. Lopez-Fabuel I et al. & Bolaños JP. Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Proc Natl Acad Sci U S A. 113:13063-13068 (2016). 3. Vicente-Gutierrez C et al. & Bolaños JP. Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour. Nat Metab. 1:201-211 (2019). 4. Bonvento G & Bolaños JP. Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metab. 33:1546-1564 (2021). None
Source: IBRO Neuroscience Reports
Author: Juan P. Bolanos
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,500
Awards: G1171198284, G176523928, G2262748287, G2972037462, G3480869486, G425668148, G4347308769, Genetic study of hypocampus glutamate neurotransmission in central mechanisms of the adaptation of neuroendocrine, cardiovascular and behavioral responses to repeated chronic stress and stress-induced neuroinflamation, G867133708, G8684520763
OpenAlex ID: W4388385992