Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15
Year: 2023
Type: article
Abstract: (Cell Reports 42, 113182, October 31, 2023) The original version of the supplemental information PDF for this paper mistakenly did not contain the supplemental figures associated with this paper. The document has now been corrected online to contain the appropriate supplemental figures. No changes were made to the figures themselves, and the scientific conclusions of the paper were unaffected. Cell Press apologizes for this mistake. Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15Devarajan et al.Cell ReportsSeptember 29, 2023In BriefDevarajan et al. identify signals provided by infection that synergize to drive CD4 effectors to develop into lung cytotoxic CD4 cells (ThCTLs) that kill influenza-virus-infected cells. They include recognition of Ag on APCs in the lung and infection-elicited type I IFN that acts by inducing IL-15 to support ThCTL generation. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,460
Awards: Age-Associated B Cells Specialized for Immunity to Pathogens?, G6473118924, G6950325777, Harnessing Age-Associated B cells for a Universal Influenza Vaccine for the Aged, VACCINE STRATEGIES TO CIRCUMVENT AGE-ASSOCIATED IMMUNE DEFECTS, Maintaining Robust T Cell Immunity For Broad Protection Against Influenza
OpenAlex ID: W4388398204