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FIGURE 1 from PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies

Year: 2023

Type: other

Abstract: PRMT5 gene expression positively correlates to DDR gene expression in cancer cells. A, Heat map of Pearson correlation coefficients between PRMT5 and HRD signature genes for breast, ovarian, pancreatic, and prostate cancer cell lines from CCLE (heat map is sum ranked). B, Dot plots showing PRMT5 expression relative to key DDR genes in ovarian and breast cancer cell lines (dots represent cell lines). C, Pearson correlation coefficient r values were deconvoluted and shown in bar graph. D, mRNA expression of select correlated DDR genes by qPCR following transient genetic knockdown of PRMT5 by shRNA in MCF7 cells (n = 2).

DOI: 10.1158/2767-9764.24512248.v1

Authors: Jack Carter, Michael Hulse, Monisha Sivakumar, Jessica Burtell, Venkat Thodima, Min Wang, Anjana Agarwal, Komali Vykuntam, Jacob Spruance, Neha Bhagwat, Joseph Rager, Bruce Ruggeri, Peggy Scherle, Koichi Ito

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4388423425

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