Dysregulation of the Environmental Sensor Aryl Hydrocarbon Receptor Affects Differentiation of Human Colon Organoids
Year: 2023
Type: article
Abstract: Gut disorders such as inflammatory bowel disease (IBD) have increased dramatically in the past 50 years, driven by incompletely defined environmental factors, including diet, with reduced intake of substances such as indole compounds, which function as aryl hydrocarbon receptor (AHR) ligands. The AHR resides in the cytoplasm complexed with chaperones, and upon ligand binding translocates to the nucleus where it dimerizes with its partner aryl hydrocarbon nuclear translocator, and initiates the transcription of a wide range of target genes.
Authors: Anke Liebert, Michael Shapiro, Muralidhara Rao Maradana, Ying Li, Nick Powell, Matthias Zilbauer, Brigitta Stockinger
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,750
OpenAlex ID: W4388452140