Work

Therapeutic Phages as Modulators of the Immune Response: Practical Implications

Year: 2023

Type: article

Abstract: While the medical community awaits formal proof of the efficacy of phage therapy, as is required by evidence-based medicine, existing data suggest that phages could also be applied based on their non-antibacterial action, especially phage-mediated immunomodulation. Promising avenues have been revealed by findings indicating that phages may mediate diverse actions in the immune system, while the list of phages able to dampen the aberrant immunity associated with a variety of disorders continuously grows. Here we summarize what is known in this field and possible options for the future. While available data are still scarce and preliminary, it appears that "phage repurposing" is worthy of more research, which could reveal new perspectives on applying phage therapy in contemporary medicine.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciad483

Authors: Andrzej Górski, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Monika Kniotek, Sławomir Letkiewicz

Institutions: Medical University of Warsaw, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Jan Długosz University

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Society of Clinical Microbiology and Infectious Diseases, Warszawski Uniwersytet Medyczny, Agencja Badań Medycznych, European Regional Development Fund