Get started
Work

LncRNAs‐circRNAs as Rising Epigenetic Binary Superstars in Regulating Lipid Metabolic Reprogramming of Cancers

Year: 2023
Type: review
Abstract: As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is shown to support carcinogenesis, progression, distal metastasis, and chemotherapy resistance by generating ATP, biosynthesizing macromolecules, and maintaining appropriate redox status. Notably, increasing evidence confirms that lipid metabolic reprogramming is under the control of dysregulated non-coding RNAs in cancer, especially lncRNAs and circRNAs. This review highlights the present research findings on the aberrantly expressed lncRNAs and circRNAs involved in the lipid metabolic reprogramming of cancer. Emphasis is placed on their regulatory targets in lipid metabolic reprogramming and associated mechanisms, including the clinical relevance in cancer through lipid metabolism modulation. Such insights will be pivotal in identifying new theranostic targets and treatment strategies for cancer patients afflicted with lipid metabolic reprogramming.
DOI: 10.1002/advs.202303570
Authors: Shanshan Liu, Benzheng Jiao, Hongguang Zhao, Xinyue Liang, Fengyan Jin, Xiaodong Liu, Ji‐Fan Hu
Language: English
Subfield: Cancer Research
Open Access status: gold
Estimated APC paid: $5,720
Funders: California Institute of Regenerative Medicine, Natural Science Foundation of Jilin Province, National Natural Science Foundation of China, People's Government of Jilin Province, Education Department of Jilin Province, National Key Research and Development Program of China
Awards: G1066976473, G115530167, G338883960, G5301971943, G5697908871, G5794144238, G6117609836, G7443169238, G7600836426, G8240331401
OpenAlex ID: W4388485358
FWCI: 0.723
Cites: 200
Cited by: 28
Related to: 10