FIGURE 1 from Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans
Year: 2023
Type: other
Abstract: Approach and proof of concept. A, Hypotheses: proteins encoded by L1 are expected to be recognized as tumor-associated antigens and become targets for antibody response. This response is stimulated by the cGAS-STING-mediated induction of inflammation. Circulating Abs to L1 antigens can be used as cancer biomarkers if detected by anti-ORF1p and anti-ORF2p immunoassays. Comparison of antibody levels in healthy individuals (N = 137) and patients with cancer (N = 331) in the assays for anti-ORF1p (B), anti-ORF2p (C), and p53 (D). The significance of differences is assessed by Mann–Whitney U test. E, Spearman correlation between anti-ORF1p IgG titers and anti-p53 IgG signals in serum samples of patients with cancer (N = 331). All P value less than 0.05 is considered significant.
Authors: Alexandra V. Vylegzhanina, Ivan A. Bespalov, Ksenia A. Novototskaya-Vlasova, Brandon M. Hall, Anatoli S. Gleiberman, Han Yu, Olga V. Leontieva, Katerina I. Leonova, Oleg V. Kurnasov, Andrei L. Osterman, Grace K. Dy, Alexey A. Komissarov, Elena Vasilieva, Jeff Gehlhausen, Akiko Iwasaki, Christine B. Ambrosone, Takemasa Tsuji, Junko Matsuzaki, Kunle Odunsi, Ekaterina L. Andrianova, Andrei V. Gudkov
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4388490276