Work

Regulation of aging by NELF-A and RNA polymerase II elongation

Year: 2023

Type: article

Abstract: Epigenetic regulation of aging: Aging is defined as the gradual decline of physiological function and cellular integrity, causing organismal vulnerability to age-onset diseases and morbidity.Studies in different animal models have led to the identification of twelve aging hallmarks that shared several features: its age-associated manifestation, how experimental manipulation of individual hallmark may alter the trajectory of aging, as well as their interdependence during the process of aging.These hallmarks include genomic instability, telomere attrition, loss of proteostasis, disabled macro-autophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, chronic inflammation, dysbiosis, altered intercellular communication and epigenetic alterations (Lopez-Otin et al., 2023).

Source: Neural Regeneration Research

DOI: 10.4103/1673-5374.387989

Authors: Chin-Tong Ong, Zhen-Kai Ngian

Institutions: Temasek Life Sciences Laboratory, National University of Singapore, Agency for Science, Technology and Research, Harvard University, Institute of Molecular and Cell Biology

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500