A comparison of structural morphometry in children and adults with persistent developmental stuttering
Year: 2023
Type: article
Abstract: -weighted structural scans were obtained from 166 individuals who stutter (74 children, 92 adults; ages 3-58) and 191 controls (92 children, 99 adults; ages 3-53) from eight prior studies in our laboratories. Mean size and gyrification measures were extracted using FreeSurfer software for each cortical region of interest. FreeSurfer software was also used to generate subcortical volumes for regions in the automatic subcortical segmentation. For cortical analyses, separate ANOVA analyses of size (surface area, cortical thickness) and gyrification (local gyrification index) measures were conducted to test for a main effect of diagnosis (stuttering, control) and the interaction of diagnosis-group with age-group (children, adults) across cortical regions. Cortical analyses were first conducted across a set of regions that comprise the speech network and then in a second whole-brain analysis. Next, separate ANOVA analyses of volume were conducted across subcortical regions in each hemisphere. False discovery rate corrections were applied for all analyses. Additionally, we tested for correlations between structural morphometry and stuttering severity. Analyses revealed thinner cortex in children who stutter compared with controls in several key speech-planning regions, with significant correlations between cortical thickness and stuttering severity. These differences in cortical size were not present in adults who stutter, who instead showed reduced gyrification in the right inferior frontal gyrus. Findings suggest that early cortical anomalies in key speech planning regions may be associated with stuttering onset. Persistent stuttering into adulthood may result from network-level dysfunction instead of focal differences in cortical morphometry. Adults who stutter may also have a more heterogeneous neural presentation than children who stutter due to their unique lived experiences.
Source: Brain Communications
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,443
Funders: National Science Foundation, American Speech-Language-Hearing Foundation, Acoustical Society of America, Fondation Pour l'Audition, National Science Foundation of Sri Lanka, National Institute on Deafness and Other Communication Disorders, National Center for Advancing Translational Sciences
Awards: G2509604292, Predictors of Speech Motor Sequence Learning in Neurological Disorders, G5266476318, G7152662830, MRI: Acquisition of a 3-Tesla Magnetic Resonance Imaging (MRI) Scanner for Cognitive and Systems Neuroscience, Advanced Research Training in Communication Sciences and Disorders, Sequencing and Initiation in Speech Production, A longitudinal study of neural network development in children who stutter
OpenAlex ID: W4388537686