Racial disparities in prostate cancer mortality: a model-based decomposition of contributing factors
Year: 2023
Type: article
Abstract: To investigate the relative contributions of natural history and clinical interventions to racial disparities in prostate cancer mortality in the United States, we extended a model that was previously calibrated to Surveillance, Epidemiology, and End Results (SEER) incidence rates for the general population and for Black men. The extended model integrated SEER data on curative treatment frequencies and cancer-specific survival. Starting with the model for all men, we replaced up to 9 components with corresponding components for Black men, projecting age-standardized mortality rates for ages 40-84 years at each step. Based on projections in 2019, the increased frequency of developing disease, more aggressive tumor features, and worse cancer-specific survival in Black men diagnosed at local-regional and distant stages explained 38%, 34%, 22%, and 8% of the modeled disparity in mortality. Our results point to intensified screening and improved care in Black men as priority areas to achieve greater equity.
Source: JNCI Monographs
Institutions: Fred Hutch Cancer Center, University of Washington Medical Center, Oregon Health & Science University, OHSU Knight Cancer Institute, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, Weill Cornell Medicine, Case Western Reserve University, University of Michigan
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1457603133, Modeling Precision Interventions for Prostate Cancer Control, SECONDARY TREATMENT AFTER RADICAL (STAR) PROSTATECTOMY IN BLACK MEN., Modeling to Improve Prostate Cancer Outcomes Across Diverse Populations, Statistical modeling to support population and translational cancer research, The Pacific Northwest Prostate Cancer SPORE
OpenAlex ID: W4388556586