Nimg-14. Autopsy-based Radio-pathomic Maps Reveal Demographic Factors Impact the Presence of Tumor Outside Contrast Enhancement in Glioma Patients
Year: 2023
Type: conference-abstract
Abstract: Gliomas are vastly heterogenous tumors with wide-ranging pathological signatures; as such, there is a pressing need to understand how individualized factors affect tumor growth patterns to develop treatment plans and improve prognosis. This study used autopsy-based radio-pathomic maps of tumor probability to test the hypothesis that differences in patient sex and age impact the presence of non-enhancing tumor. This study used pre-surgical imaging and demographic data from 501 glioma patients from the UCSF-PDGM dataset. Specifically, T1, T1C, FLAIR, and ADC images were used to generate maps of tumor probability using a previously validated model. This model used autopsy tissue aligned to imaging as ground truth to develop models sensitive to identifying areas of non-enhancing tumor outside of traditional imaging signatures. Thresholded maps were used to delineate areas of tumor presence, and the non-enhancing tumor volume was computed for each patient as the predicted high probability tumor volume within non-enhancing FLAIR hyperintensity. A general linear model was then fit to assess the effect of age and sex on non-enhancing tumor volumes, using tumor grade and contrast-enhancing volume as covariates. Male patients trended towards greater non-enhancing tumor volumes compared to female patients (B=5676.6, p=0.053). Older patients were also found to have less non-enhancing tumor volume compared to younger patients (B=-261.1, p=0.015). These results suggest that demographic characteristics influence the progression of tumor beyond the angiogenic tumor mass and may therefore influence treatment efficacy and prognoses. Future research is essential to understanding how these sex differences relate to the worse prognosis historically observed for males with glioma, and how the reduced presence of non-enhancing tumor in older patients relates to a reduction in plasticity-induced tumor propagation.
Source: Neuro-Oncology
Institution: Medical College of Wisconsin
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4388588397