OC 61.2 MiR-146a-Mimic Therapy Modulates Platelet Reactivity Preventing Mortality Caused by Pulmonary Embolism Model
Year: 2023
Type: article
Abstract: induced, Akt-dependent thromboxane generation was blunted, and secondary-wave aggregation was inhibited in a thromboxane-dependent manner.Intravenously-administered puromycin reduced injury-induced clot size, and delayed primary but not final tail clip hemostasis, nor hemostasis following jugular vein puncture.In contrast, these mice were protected from thrombin-induced pulmonary embolism (PE), and adoptive transfer of translation-inhibited platelets into untreated mice inhibited PE.Conclusion(s): Constitutive plasma GFH-driven translation regulates platelet GPCR reactivity to balance hemostatic and thrombotic potential.Ribosomeassociated chaperone clients Mtor/Akt manifest labile protein levels under proteostatic stress conditions.
Authors: S. Aguila, J. Garcia-Cañaveras, A. De los Reyes-Garcia, L. Zapata-Martinez, N. Garcia-Barbera, P. Guijarro, M. Lozano, B. Payrastre, J. Rivera, M. Gratacap, A. Lahoz, M. Kortylewski, R. Gonzalez-Conejero, C. Martinez
Institutions: University of Kentucky, Centro Regional de Hemodonación, Instituto Murciano de Investigación Biosanitaria, Instituto de Investigación Sanitaria La Fe, Hospital General Universitario Morales Meseguer, Universidad de Murcia, Inserm, Centre Hospitalier Universitaire de Toulouse, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, City Of Hope National Medical Center, City of Hope, Beckman Research Institute
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,250
OpenAlex ID: W4388598273