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OC 32.1 Risk Factors for Venous Thrombosis after Discharge from Medical Hospitalizations: The Medical Inpatient Thrombosis and Hemostasis (MITH) Study

Year: 2023

Type: article

Abstract: Results: Elevated levels of miR-145 expression in plasma were associated with decreased risk of VTE (Table 1).Participants with miR-145 levels in the highest quartile had a 50% lower risk of VTE (HR 0.50, 95% CI 0.37-0.66)compared with those with miR-145 levels in the lowest quartile in age-and sex-adjusted analysis.Risk estimates remained virtually the same after further adjustment for body mass index. Conclusion(s):Our results indicate that expression levels of miR-145 are inversely associated with VTE risk.Our finding of a protective role of miR-145 against VTE is consistent with previous experimental data.Future studies are needed to confirm the potential of miR-145 as a predictive biomarker and for preventive treatment of VTE.

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2023.100644

Authors: R. Thomas, K. Wilkinson, A. Sparks, M. Gergi, A. Repp, N. Roetker, N. Smith, P. Muthukrishnan, N. Zakai

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250

OpenAlex ID: W4388598616

FWCI:

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