Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Year: 2023
Type: article
Abstract: With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials.This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.
Source: The Cerebellum
Authors: Winfried Ilg, Sarah Milne, Tanja Schmitz-Hübsch, Lisa Alcock, Lukas Beichert, Enrico Bertini, Norlinah Mohamed Ibrahim, Helen Dawes, Christopher M. Gomez, Hasmet Hanagasi, Kirsi M. Kinnunen, Martina Minnerop, Andrea H. Németh, Jane Newman, Yi Shiau Ng, Clara Rentz, Bedia Samanci, Vrutangkumar V. Shah, Susanna Summa, Gessica Vasco, James McNames, Fay B. Horak, on behalf of the Ataxia Global Initiative (AGI) working group Digital Motor Biomarkers
Institutions: Hertie Institute for Clinical Brain Research, University of Tübingen, The University of Melbourne, Monash Health, Murdoch Children's Research Institute, Monash University, Max Delbrück Center, Charité – Universitätsmedizin Berlin, NIHR Newcastle Biomedical Research Centre, Newcastle University, Bambino Gesù Children's Hospital, National University of Malaysia, University of Exeter, University of Chicago, Istanbul University, Ixico (United Kingdom), Forschungszentrum Jülich, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, University of Oxford, Wellcome Centre for Mitochondrial Research, Oregon Health & Science University, APDM (United States), Istituti di Ricovero e Cura a Carattere Scientifico, Portland State University
Language: English
Field: Health Professions
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Award: G970972667
OpenAlex ID: W4388633306