FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Year: 2023
Type: other
Abstract: Recurrently mutated genes in Hodgkin lymphoma. The frequency and type of mutations affecting genes mutated in 3 or more patients in our cohort are shown in each row. Genes determined to be significantly mutated using MuSiC and/or dN/dScv (FDR < 0.05) are highlighted (SMG = significantly mutated gene). The open SMG shape indicates that a gene was determined to be an SMG only when HL-513 was excluded from the statistical analysis. The filled SMG shape indicates a gene that was determined to be an SMG only when HL-513 was included in the statistical analysis. The darkest SMG shape indicates that a gene was determined to be an SMG in all analyses (including and excluding HL-513). The bar graph on the right summarizes the frequency of mutations for that gene across the entire cohort. For genes with multiple mutations in a single patient, only one mutation type is shown, prioritized by the order listed in the legend.
Authors: Felicia Gomez, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, Christopher A. Miller, Haley Abel, Yi-Shan Li, David A. Russler-Germain, Kilannin Krysiak, Marcus P. Watkins, Cody A. Ramirez, Alina Schmidt, Fernanda Martins Rodrigues, Lee Trani, Ajay Khanna, Julia A. Wagner, Robert S. Fulton, Catrina C. Fronick, Michelle D. O'Laughlin, Timothy Schappe, Amanda F. Cashen, Neha Mehta-Shah, Brad S. Kahl, Jason Walker, Nancy L. Bartlett, Malachi Griffith, Todd A. Fehniger, Obi L. Griffith
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4388697548