FIGURE 3 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Year: 2023
Type: other
Abstract: snRNA-seq of Patient HL-248. A, UMAP representation of unsupervised clustering of nuclei sequenced in HL-248. B, UMAP of HL-248 clusters with cell-type labels determined by celldex and SingleR. C, UMAP of HL-248 where highlighted nuclei are nuclei with a VAF > 0 for the EIF4A2 variant uncovered in this sample's deep exome (chr3:186783634 T/A). D, UMAP of HL-248 where highlighted nuclei are nuclei that express an expanded BCR clonotype. E, Genes differentially expressed between cluster 3 and all other B cells are displayed as either downregulated with a significant P value (blue) or upregulated with a significant P value (orange).
Authors: Felicia Gomez, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, Christopher A. Miller, Haley Abel, Yi-Shan Li, David A. Russler-Germain, Kilannin Krysiak, Marcus P. Watkins, Cody A. Ramirez, Alina Schmidt, Fernanda Martins Rodrigues, Lee Trani, Ajay Khanna, Julia A. Wagner, Robert S. Fulton, Catrina C. Fronick, Michelle D. O'Laughlin, Timothy Schappe, Amanda F. Cashen, Neha Mehta-Shah, Brad S. Kahl, Jason Walker, Nancy L. Bartlett, Malachi Griffith, Todd A. Fehniger, Obi L. Griffith
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4388697589